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1

Development of the Olfactory Epithelium and Nasal Glands in TMEM16A-/- and TMEM16A+/+ Mice

Maurya, Devendra Kumar, Henriques, Tiago, Marini, Monica, Pedemonte, Nicoletta, Galietta, Luis J. V., Rock, Jason R., Harfe, Brian D., Menini, Anna, Reisert, Johannes

Journal:

Year:

2015

Language:

english

File:

PDF, 14.47 MB

english, 2015

2

Synthesis of 4-thiophen-2′-yl-1,4-dihydropyridines as potentiators of the CFTR chloride channel

Francesca Cateni, Marina Zacchigna, Nicoletta Pedemonte, Luis J.V. Galietta, Marco T. Mazzei, Paola Fossa, Michele Giampieri, Mauro Mazzei

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 623 KB

english, 2009

3

Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening

Ori Kalid, Martin Mense, Sharon Fischman, Alina Shitrit, Hermann Bihler, Efrat Ben-Zeev, Nili Schutz, Nicoletta Pedemonte, Philip J. Thomas, Robert J. Bridges, Diana R. Wetmore, Yael Marantz, Hanoch S

Journal:

Journal of Computer-Aided Molecular Design

Year:

2010

Language:

english

File:

PDF, 1.17 MB

english, 2010

4

Rational design of a nonpeptide general chemical scaffold for reversible inhibition of PDZ domain interactions

Naoaki Fujii, Jose J. Haresco, Kathleen A.P. Novak, Robert M. Gage, Nicoletta Pedemonte, David Stokoe, Irwin D. Kuntz, R. Kiplin Guy

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 370 KB

english, 2007

5

4-Chlorobenzo[F]isoquinoline (CBIQ), a novel activator of CFTR and ΔF508 CFTR

Meena Murthy, Nicoletta Pedemonte, Lesley MacVinish, Luis Galietta, Alan Cuthbert

Journal:

European Journal of Pharmacology

Year:

2005

Language:

english

File:

PDF, 187 KB

english, 2005

6

Block of CFTR-dependent chloride currents by inhibitors of multidrug resistance-associated proteins

Tullia Diena, Raffaella Melani, Emanuela Caci, Nicoletta Pedemonte, Elvira Sondo, Olga Zegarra-Moran, Luis J.V. Galietta

Journal:

European Journal of Pharmacology

Year:

2007

Language:

english

File:

PDF, 930 KB

english, 2007

7

Cystic Fibrosis: A New Target for 4-Imidazo[2,1-b]thiazole-1,4-dihydropyridines

Budriesi, Roberta, Ioan, Pierfranco, Leoni, Alberto, Pedemonte, Nicoletta, Locatelli, Alessandra, Micucci, Matteo, Chiarini, Alberto, Galietta, Luis J. V.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 964 KB

english, 2011

8

Asymmetric 4-Aryl-1,4-dihydropyridines Potentiate Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

Dr. Michele Giampieri, Dr. Nicolas Vanthuyne, Dr. Erika Nieddu, Dr. Marco T. Mazzei, Dr. Maria Anzaldi, Dr. Nicoletta Pedemonte, Dr. Luis J. V. Galietta, Prof. Christian Roussel, Prof. Mauro Mazzei

Journal:

Year:

2012

Language:

english

File:

PDF, 396 KB

english, 2012

9

Ligand-based design, in silico ADME-Tox filtering, synthesis and biological evaluation to discover new soluble 1,4-DHP-based CFTR activators

Visentin, Sonja, Ermondi, Giuseppe, Medana, Claudio, Pedemonte, Nicoletta, Galietta, Luis, Caron, Giulia

Journal:

European Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 671 KB

english, 2012

10

Association of TMEM16A chloride channel overexpression with airway goblet cell metaplasia

Scudieri, Paolo, Caci, Emanuela, Bruno, Silvia, Ferrera, Loretta, Schiavon, Marco, Sondo, Elvira, Tomati, Valeria, Gianotti, Ambra, Zegarra-Moran, Olga, Pedemonte, Nicoletta, Rea, Federico, Ravazzolo,

Journal:

The Journal of Physiology

Year:

2012

Language:

english

File:

PDF, 2.44 MB

english, 2012

11

The search for a common structural moiety among selected pharmacological correctors of the mutant CFTR chloride channel

Nieddu, Erika, Pollarolo, Benedetta, Mazzei, Marco T, Anzaldi, Maria, Schenone, Silvia, Pedemonte, Nicoletta, Pesce, Emanuela, Galietta, Luis JV, Mazzei, Mauro

Journal:

Future Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.54 MB

english, 2014

12

Evidence against the Rescue of Defective ΔF508-CFTR Cellular Processing by Curcumin in Cell Culture and Mouse Models

Song, Yuanlin, Sonawane, N. D., Salinas, Danieli, Qian, Liman, Pedemonte, Nicoletta, Galietta, Luis J. V., Verkman, A. S.

Journal:

Journal of Biological Chemistry

Year:

2004

Language:

english

File:

PDF, 647 KB

english, 2004

13

Spatial organization of displaced ganglion cells in the chick retina

DEPLANO, STEFANIA, PEDEMONTE, NICOLETTA

Journal:

Visual Neuroscience

Year:

2002

Language:

english

File:

PDF, 943 KB

english, 2002

14

Synthesis and structure–activity relationship of aminoarylthiazole derivatives as correctors of the chloride transport defect in cystic fibrosis

Pesce, Emanuela, Bellotti, Marta, Liessi, Nara, Guariento, Sara, Damonte, Gianluca, Cichero, Elena, Galatini, Andrea, Salis, Annalisa, Gianotti, Ambra, Pedemonte, Nicoletta, Zegarra-Moran, Olga, Fossa

Journal:

European Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 5.66 MB

english, 2015

15

Gelsolin Secretion in Interleukin-4–treated Bronchial Epithelia and in Asthmatic Airways

Candiano, Giovanni, Bruschi, Maurizio, Pedemonte, Nicoletta, Caci, Emanuela, Liberatori, Sabrina, Bini, Luca, Pellegrini, Carlo, Viganò, Mario, O'Connor, Brian J., Lee, Tak H., Galietta, Luis J. V., Z

Journal:

American Journal of Respiratory and Critical Care Medicine

Year:

2005

Language:

english

File:

PDF, 437 KB

english, 2005

16

Novel Hits in the Correction of ΔF508-Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Protein: Synthesis, Pharmacological, and ADME Evaluation of Tetrahydropyrido[4,3-d]pyrimidines for the Potential Treatment of Cystic Fibrosis

Pesci, Elisabetta, Bettinetti, Laura, Fanti, Paola, Galietta, Luis J.V., La Rosa, Salvatore, Magnoni, Letizia, Pedemonte, Nicoletta, Sardone, Gian Luca, Maccari, Laura

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 2.58 MB

english, 2015

17

Epithelial Sodium Channel Inhibition in Primary Human Bronchial Epithelia by Transfected siRNA

Caci, Emanuela, Melani, Raffaella, Pedemonte, Nicoletta, Yueksekdag, Guelnihal, Ravazzolo, Roberto, Rosenecker, Joseph, Galietta, Luis J. V., Zegarra-Moran, Olga

Journal:

American Journal of Respiratory Cell and Molecular Biology

Year:

2009

Language:

english

File:

PDF, 276 KB

english, 2009

18

Phenylhydrazones as Correctors of a Mutant Cystic Fibrosis Transmembrane Conductance Regulator

Nieddu, Erika, Pollarolo, Benedetta, Mazzei, Marco T., Anzaldi, Maria, Schenone, Silvia, Pedemonte, Nicoletta, Galietta, Luis J. V., Mazzei, Mauro

Journal:

Archiv der Pharmazie

Year:

2016

Language:

english

File:

PDF, 797 KB

english, 2016

19

In vitro recapitulation of the site-specific editing (to wild-type) of mutant IDS mRNA transcripts, and the characterization of IDS protein translated from the edited mRNAs

Lualdi, Susanna, Del Zotto, Genny, Zegarra-Moran, Olga, Pedemonte, Nicoletta, Corsolini, Fabio, Bruschi, Maurizio, Tomati, Valeria, Amico, Giulia, Candiano, Giovanni, Dardis, Andrea, Cooper, David N.,

Journal:

Year:

2017

Language:

english

File:

PDF, 2.05 MB

english, 2017

20

Therapeutic approaches to CFTR dysfunction: From discovery to drug development

Li, Hongyu, Pesce, Emanuela, Sheppard, David N., Singh, Ashvani K., Pedemonte, Nicoletta

Journal:

Journal of Cystic Fibrosis

Year:

2017

Language:

english

File:

PDF, 1.37 MB

english, 2017

21

High-throughput screening identifies FAU protein as a regulator of mutant cystic fibrosis transmembrane conductance regulator channel

Tomati, Valeria, Pesce, Emanuela, Caci, Emanuela, Sondo, Elvira, Scudieri, Paolo, Marini, Monica, Amato, Felice, Castaldo, Giuseppe, Ravazzolo, Roberto, Galietta, Luis JV, Pedemonte, Nicoletta

Journal:

Journal of Biological Chemistry

Year:

2017

Language:

english

File:

PDF, 2.50 MB

english, 2017

22

Synthesis and biological evaluation of novel thiazole- VX-809 hybrid derivatives as F508del correctors by QSAR-based filtering tools

Liessi, Nara, Cichero, Elena, Pesce, Emanuela, Arkel, Maria, Salis, Annalisa, Tomati, Valeria, Paccagnella, Matteo, Damonte, Gianluca, Tasso, Bruno, Galietta, Luis J.V., Pedemonte, Nicoletta, Fossa, P

Journal:

European Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 6.87 MB

english, 2017

23

Pharmacological Correctors of Mutant CFTR Mistrafficking

Pedemonte, Nicoletta, Galietta, Luis J. V.

Journal:

Frontiers in Pharmacology

Year:

2012

Language:

english

File:

PDF, 997 KB

english, 2012

24

SWATH label-free proteomics for cystic fibrosis research

Braccia, Clarissa, Tomati, Valeria, Caci, Emanuela, Pedemonte, Nicoletta, Armirotti, Andrea

Journal:

Journal of Cystic Fibrosis

Year:

2018

Language:

english

File:

PDF, 227 KB

english, 2018

25

Chemically modified hCFTR mRNAs recuperate lung function in a mouse model of cystic fibrosis

Haque, A. K. M. Ashiqul, Dewerth, Alexander, Antony, Justin S., Riethmüller, Joachim, Schweizer, Georg R., Weinmann, Petra, Latifi, Ngadhnjim, Yasar, Hanzey, Pedemonte, Nicoletta, Sondo, Elvira, Weide

Journal:

Scientific Reports

Year:

2018

Language:

english

File:

PDF, 2.72 MB

english, 2018

26

High-Content Screening Identifies Vanilloids as a Novel Class of Inhibitors of NET Formation

Sondo, Elvira, Bertelli, Roberta, Pesce, Emanuela, Ghiggeri, Gian Marco, Pedemonte, Nicoletta

Journal:

Frontiers in Immunology

Year:

2019

Language:

english

File:

PDF, 6.49 MB

english, 2019

27

High-Throughput Screening for Modulators of CFTR Activity Based on Genetically Engineered Cystic Fibrosis Disease-Specific iPSCs

Merkert, Sylvia, Schubert, Madline, Olmer, Ruth, Engels, Lena, Radetzki, Silke, Veltman, Mieke, Scholte, Bob J., Zöllner, Janina, Pedemonte, Nicoletta, Galietta, Luis J.V., von Kries, Jens P., Martin,

Journal:

Stem Cell Reports

Year:

2019

File:

PDF, 3.40 MB

2019

28

Exploitation of a novel biosensor based on the full-length human F508del-CFTR with computational studies, biochemical and biological assays for the characterization of a new Lumacaftor/Tezacaftor analogue

D’Ursi, Pasqualina, Uggeri, Matteo, Urbinati, Chiara, Millo, Enrico, Paiardi, Giulia, Milanesi, Luciano, Ford, Robert C., Clews, Jack, Meng, Xin, Bergese, Paolo, Ridolfi, Andrea, Pedemonte, Nicoletta,

Journal:

Sensors and Actuators B: Chemical

Year:

2019

Language:

english

File:

PDF, 3.40 MB

english, 2019

29

CFTR processing, trafficking and interactions

Amaral, Margarida D., Hutt, Darren M, Tomati, Valeria, Botelho, Hugo M., Pedemonte, Nicoletta

Journal:

Journal of Cystic Fibrosis

Year:

2019

Language:

english

File:

PDF, 455 KB

english, 2019

30

Editorial: Emerging Therapeutic Approaches for Cystic Fibrosis

Lopes-Pacheco, Miquéias, Pedemonte, Nicoletta, Kicic, Anthony

Journal:

Frontiers in Pharmacology

Year:

2019

Language:

english

File:

PDF, 651 KB

english, 2019

31

Editorial: Emerging Therapeutic Approaches for Cystic Fibrosis

Lopes-Pacheco, Miquéias, Pedemonte, Nicoletta, Kicic, Anthony

Journal:

Frontiers in Pharmacology

Year:

2019

File:

PDF, 651 KB

2019

32

Discovery of a picomolar potency pharmacological corrector of the mutant CFTR chloride channel

Pedemonte, Nicoletta, Bertozzi, Fabio, Caci, Emanuela, Sorana, Federico, Di Fruscia, Paolo, Tomati, Valeria, Ferrera, Loretta, RodrÃguez-Gimeno, Alejandra, Berti, Francesco, Pesce, Emanuela, Sondo, E

Journal:

Science Advances

Year:

2020

File:

PDF, 2.79 MB

2020

33

Corrigendum: Normal Calcium-Activated Anion Secretion in a Mouse Selectively Lacking TMEM16A in Intestinal Epithelium

Vega, GÃ©nesis, GuequÃ©n, Anita, Johansson, Malin E. V., Arike, Liisa, MartÃnez-Abad, Beatriz, NystrÃ¶m, Elisabeth E. L., Scudieri, Paolo, Pedemonte, Nicoletta, Millar-BÃ¼chner, Pamela, Philp, Amber

Journal:

Frontiers in Physiology

Year:

2019

File:

PDF, 112 KB

2019

34

Recent Strategic Advances in CFTR Drug Discovery: An Overview

Rusnati, Marco, DâUrsi, Pasqualina, Pedemonte, Nicoletta, Urbinati, Chiara, Ford, Robert C., Cichero, Elena, Uggeri, Matteo, Orro, Alessandro, Fossa, Paola

Journal:

International Journal of Molecular Sciences

Year:

2020

File:

PDF, 3.03 MB

2020

35

Characterization of the Mechanism of Action of RDR01752, a Novel Corrector of F508del-CFTR

Lopes-Pacheco, MiquÃ©ias, Silva, Iris A.L., Turner, Mark J., Carlile, Graeme W., Sondo, Elvira, Thomas, David Y., Pedemonte, Nicoletta, Hanrahan, John W., Amaral, Margarida D.

Journal:

Biochemical Pharmacology

Year:

2020

File:

PDF, 1.25 MB

2020

36

Sphingolipids and plasma membrane hydrolases in human primary bronchial cells during differentiation and their altered patterns in cystic fibrosis

Loberto, Nicoletta, Mancini, Giulia, Bassi, Rosaria, Carsana, Emma Veronica, Tamanini, Anna, Pedemonte, Nicoletta, Dechecchi, Maria Cristina, Sonnino, Sandro, Aureli, Massimo

Journal:

Glycoconjugate Journal

Year:

2020

File:

PDF, 822 KB

2020

37

Proteomics and Metabolomics for Cystic Fibrosis Research

Liessi, Nara, Pedemonte, Nicoletta, Armirotti, Andrea, Braccia, Clarissa

Journal:

International Journal of Molecular Sciences

Year:

2020

File:

PDF, 1.81 MB

2020

38

Synthesis and biological evaluation of thiazole derivatives on basic defects underlying cystic fibrosis

Pesce, Emanuela, Pedemonte, Nicoletta, Leoni, Alberto, Locatelli, Alessandra, Morigi, Rita

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2020

File:

PDF, 634 KB

2020

39

Discovery of novel VX-809 hybrid derivatives as F508del-CFTR correctors by molecular modeling, chemical synthesis and biological assays

Parodi, Alice, Righetti, Giada, Pesce, Emanuela, Salis, Annalisa, Tasso, Bruno, Urbinati, Chiara, Tomati, Valeria, Damonte, Gianluca, Rusnati, Marco, Pedemonte, Nicoletta, Cichero, Elena, Millo, Enric

Journal:

European Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 3.22 MB

2020

40

Editorial: Special Issue on âTherapeutic Approaches for Cystic Fibrosisâ

Pedemonte, Nicoletta

Journal:

International Journal of Molecular Sciences

Year:

2020

File:

PDF, 209 KB

2020

41

Molecular Docking and QSAR Studies as Computational Tools Exploring the Rescue Ability of F508del CFTR Correctors

Righetti, Giada, Casale, Monica, Liessi, Nara, Tasso, Bruno, Salis, Annalisa, Tonelli, Michele, Millo, Enrico, Pedemonte, Nicoletta, Fossa, Paola, Cichero, Elena

Journal:

International Journal of Molecular Sciences

Year:

2020

File:

PDF, 3.34 MB

2020

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